methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

Base Information

Chemical Name:methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate
CAS No.:610313-13-8
Molecular Formula:C₃₃H₄₈O₈S
Molecular Weight:604.805
Hs Code.:

Synonyms:methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

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Chemical Property of methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

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Technology Process of methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

There total 6 articles about methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: methyl 7α-benzyloxymethoxy-3β,4β-dihydroxycholan-24-oate

: methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5β-cholan-24-oate

: 610313-13-8
methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

Guidance literature:: methyl 7α-benzyloxymethoxy-3β,4β-dihydroxycholan-24-oate; With thionyl chloride; triethylamine; In tetrahydrofuran;

With ruthenium trichloride; sodium periodate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(03)01598-3

Reference yield:

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

: 610313-13-8
methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuOK; O₂ / 2-methyl-propan-2-ol

1.2: 71 percent / CH₂N₂ / diethyl ether; methanol; CHCl₃

2.1: 83 percent / i-Pr₂NEt / CH₂Cl₂

3.1: 44 percent / NaBH₃CN / CHCl₃; methanol

4.1: SOCl₂; Et₃N / tetrahydrofuran

4.2: 65 percent / RuCl₃*nH₂O; NaIO₄ / tetrahydrofuran

With thionyl chloride; potassium tert-butylate; oxygen; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; tert-butyl alcohol;
DOI:10.1016/S0040-4039(03)01598-3

Reference yield:

: methyl 7α-benzyloxymethoxy-3β,4β-dihydroxycholan-24-oate

: 610313-13-8
methyl 7α-benzyloxymethoxy-3β,4β-cyclic sulfate-5α-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; Et₃N / tetrahydrofuran / 0.17 h / 0 °C

2: 367 mg / NaIO₄; RuCl₃; aq. phosphate buffer / acetonitrile; CCl₄ / 0.33 h

With ruthenium trichloride; sodium periodate; thionyl chloride; phosphate buffer; triethylamine; In tetrahydrofuran; tetrachloromethane; acetonitrile;
DOI:10.1016/j.tet.2004.02.075