Technology Process of 3-benzyl-N-(p-tolyl)piperidine
There total 3 articles about 3-benzyl-N-(p-tolyl)piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1 ,5-pentanediol; p-toluidine;
With
Ir(1,2,3,4,5-pentamethylcyclopentadienyl)(2-diphenylphosphinobenzenesulfonate)Cl;
In
toluene;
at 150 ℃;
for 16h;
Inert atmosphere;
benzaldehyde;
With
D-(+)-camphor sulfonic acid;
In
toluene;
at 150 ℃;
for 20h;
Inert atmosphere;
With
formic acid;
In
toluene;
at 150 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201204582
- Guidance literature:
-
C19H19NO;
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
at 25 ℃;
for 24h;
under 760.051 Torr;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 70 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jacs.8b08733
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid / toluene / 6 h / 140 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 25 °C / 760.05 Torr
2.2: 4 h / 70 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; acetic acid;
In
ethanol; toluene;
DOI:10.1021/jacs.8b08733
