(2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

Base Information

Chemical Name:(2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline
CAS No.:503321-53-7
Molecular Formula:C₂₉H₃₁N₃O₃Si
Molecular Weight:497.669
Hs Code.:

Synonyms:(2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

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Chemical Property of (2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

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Technology Process of (2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

There total 6 articles about (2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 503321-53-7
(2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 33 g / Br₂ / 2 h / 140 - 150 °C / Irradiation

2.1: ethanol / 0.17 h

2.2: aq. NaOH / ethanol / 2 h / 0 °C

3.1: 20.6 g / 6 N aq. H₂SO₄ / 0.17 h

4.1: Fe; aq. HCl / 0.17 h

5.1: 2-ethoxy-ethanol / 160 - 180 °C

6.1: 0.84 g / bis(dibenzylideneacetone)Pd⁽⁰⁾; tri(tert-butyl)phosphine; Et₃N / tetrahydrofuran / Heating

With hydrogenchloride; palladium bis(dibenzylideneacetone)palladium⁽⁰⁾; tri-tert-butyl phosphine; sulfuric acid; bromine; iron; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; ethanol; 6.1: Heck-type reaction;
DOI:10.1021/ja028033x

Reference yield:

: 20357-21-5
2-bromo-6-nitrobenzaldehyde

: 503321-53-7
(2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: Fe; aq. HCl / 0.17 h

2: 2-ethoxy-ethanol / 160 - 180 °C

3: 0.84 g / bis(dibenzylideneacetone)Pd⁽⁰⁾; tri(tert-butyl)phosphine; Et₃N / tetrahydrofuran / Heating

With hydrogenchloride; palladium bis(dibenzylideneacetone)palladium⁽⁰⁾; tri-tert-butyl phosphine; iron; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; 3: Heck-type reaction;
DOI:10.1021/ja028033x

Reference yield:

: 58579-54-7
3-bromo-2-(bromomethyl)-1-nitrobenzene

: 503321-53-7
(2'R)-cis-5-[2',5'-dihydro-4'-((tert-butyldiphenyl)silyl)oxy-2'-furanyl]-2-aminoquinazoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 0.17 h

1.2: aq. NaOH / ethanol / 2 h / 0 °C

2.1: 20.6 g / 6 N aq. H₂SO₄ / 0.17 h

3.1: Fe; aq. HCl / 0.17 h

4.1: 2-ethoxy-ethanol / 160 - 180 °C

5.1: 0.84 g / bis(dibenzylideneacetone)Pd⁽⁰⁾; tri(tert-butyl)phosphine; Et₃N / tetrahydrofuran / Heating

With hydrogenchloride; palladium bis(dibenzylideneacetone)palladium⁽⁰⁾; tri-tert-butyl phosphine; sulfuric acid; iron; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; ethanol; 5.1: Heck-type reaction;
DOI:10.1021/ja028033x