20357-21-5

Basic information

• Product Name: 2-Bromo-6-nitrobenzaldehyde
• Synonyms: 2-Bromo-6-nitrobenzaldehyde;Benzaldehyde, 2-broMo-6-nitro-
• CAS NO: 20357-21-5
• Molecular Formula: C₇H₄BrNO₃
• Molecular Weight: 230.01556
• Product Categories: Benzaldehyde
• Mol File: 20357-21-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 86-87°C
• Boiling Point: 320.784°C at 760 mmHg
• Flash Point: 147.805°C
• Appearance: /
• Density: 1.781
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Bromo-6-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-nitrobenzaldehyde(20357-21-5)
• EPA Substance Registry System: 2-Bromo-6-nitrobenzaldehyde(20357-21-5)

Safety Data

• Hazardous Substances Data: 20357-21-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-nitrobenzaldehyde is an organic compound with the chemical formula C7H4BrNO3. It is a yellow crystalline solid commonly used as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. 2-Bromo-6-nitrobenzaldehyde is known for its strong odor and is often used as a reagent in organic synthesis. It is also used in the manufacturing of dyes, pigments, and other chemical products. 2-Bromo-6-nitrobenzaldehyde is considered to be a hazardous substance and should be handled with care due to its potential health and environmental effects.

InChI:InChI=1/C7H4BrNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-4H

Upstream product

• 55289-35-5 2-bromo-6-nitrotoluene 
• 109019-72-9 1-(2-Bromo-6-nitrobenzyl)pyridinium bromide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 552-89-6 2-nitro-benzaldehyde 
• 861106-91-4 (2-bromo-6-nitro-phenyl)-methanol 
• 397322-46-2 5-bromo-3-methylquinoline 
• 34241-39-9 azobisisobutyronitrile 
• 397321-54-9 (1-benzenesulfonyl-1H-pyrrol-2-yl)-(4-methylphenyl)-ketone 
• 58579-54-7 3-bromo-2-(bromomethyl)-1-nitrobenzene 
• 109513-33-9 C₁₅H₁₄BrN₃O₃ 
• 109513-33-9 2-Bromo-6-nitrobenzylidene(p-dimethylaminophenyl)amine N-Oxide 
• 109513-33-9 2-bromo-6-nitro-benzaldehyde-[N-(4-dimethylamino-phenyl)-oxime ] 

Downstream Products

• 135484-74-1 2-Amino-6-bromobenzaldehyde 
• 1057482-91-3 C₁₄H₁₀BrNO₄ 
• 947612-33-1 C₁₄H₁₄BrNO₅ 
• 64150-27-2 2-(methylselenyl)-6-nitrobenzaldehyde 
• 1228174-74-0 2-(2-bromo-6-nitrobenzylidene)-5-(2,3,6-trimethyl-4-methoxyphenyl)-7-(4-chlorophenyl)-5H-thiazolo-[2,3-b]pyrimidin-3(2H)-one 

Relevant articles and documents

Completion of the Set: Synthesis of the (6,X′)-Flubromazepam Positional Isomers as Standards for Forensic Analysis

Mounting concern among forensic examiners regarding the emergence of positional isomers as technically legal alternatives to scheduled benzodiazepines has encouraged the preemptive synthesis of analogues as standards. Recently, flubromazepam was identified by the Drug Enforcement Administration for future scheduling, and subsequently, 9 of the 12 possible flubromazepam isomers were synthesized. However, the three (6,X′)-isomers proved inaccessible via that approach. Herein, through a redesigned synthetic approach, the remaining three isomers were obtained, thus completing the set and enabling future forensic analysis.

Reexamination of the bromination of 2-nitrobenzaldehyde with NBS or NaBr-NaIO4 in sulfuric acid

Two literature procedures for selective bromination of 2-nitrobenzaldehyde using N-bromosuccinimide (NBS) or NaBr-NaIO4 in sulfuric acid were examined. In contrast to the reports that 4-bromo-2-nitrobenzaldehyde is formed as a single product in good yield, reactions using NBS gave a number of isomeric mono- and dibrominated products identified by spectroscopical methods and by sodium borohydride reduction to the corresponding benzyl alcohol, and reactions using NaBr-NaIO4 did not furnish any product. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Synthesis of tetra-ortho-substituted, phosphorus-containing and carbonyl-containing biaryls utilizing a Diels-Alder approach

The application of the Diels-Alder approach to biaryls (DAB) is described for the synthesis of tetra-ortho-substituted biaryl compounds containing orthogonally functionalized substituents. The syntheses of phosphorus- containing, disubstituted alkynes and