2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

Base Information

Chemical Name:2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid
CAS No.:204329-85-1
Molecular Formula:C₁₅H₁₆F₃N₃O₃
Molecular Weight:343.306
Hs Code.:

Synonyms:2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

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Chemical Property of 2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

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Technology Process of 2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

There total 13 articles about 2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2-Acetylamino-2-{3-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl}-malonic acid

: 204329-85-1
2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

Guidance literature:: In 1,4-dioxane; at 80 ℃;
DOI:10.1246/cl.1998.203

Reference yield: 92.0%

: (R)-2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

: 204329-85-1
2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

Guidance literature:: With sodium hydroxide; acetic anhydride; at 50 ℃;
DOI:10.1246/cl.1998.203

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 204329-85-1
2-Acetylamino-5-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-pentanoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: imidazole / dimethylformamide

2: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C

3: 91 percent / NH₂OH*HCl, Et₃N / ethanol / Heating

4: 98 percent / pyridine / 0 deg C -> room temp.

5: 98 percent / liq. NH₃ / diethyl ether / -78 -> -33 deg C -> room temp.

6: 1.) t-BuOCl; 2.) Et₃N / 1.) Et₂O, -50 deg C; 2.) Et₂O, -50 deg C -> room temp.

7: CSA / methanol

8: 95 percent / CBr₄, PPh₃ / toluene

9: 75 percent / NaH / dimethylformamide

10: 3M NaOH / ethanol

11: 95 percent / dioxane / 80 °C

With pyridine; 1H-imidazole; sodium hydroxide; n-butyllithium; tert-butylhypochlorite; carbon tetrabromide; camphor-10-sulfonic acid; hydroxylamine hydrochloride; ammonia; sodium hydride; triethylamine; triphenylphosphine; In 1,4-dioxane; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1246/cl.1998.203