Linogliride

Base Information

• Chemical Name: Linogliride
• CAS No.: 75358-37-1
• Molecular Formula: C₁₆H₂₂N₄O
• Molecular Weight: 286.377
• UNII: 7E521JYJ4X
• DSSTox Substance ID: DTXSID201024552
• NCI Thesaurus Code: C66015
• ChEMBL ID: CHEMBL40356
• Mol file: 75358-37-1.mol

Synonyms:linogliride;linogliride fumarate

Chemical Property of Linogliride

Chemical Property:

• Vapor Pressure: 1.88E-07mmHg at 25°C
• Boiling Point: 425.6°Cat760mmHg
• Flash Point: 211.2°C
• PSA: 40.43000
• Density: 1.18g/cm³
• LogP: 2.00620
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 286.17936134
• Heavy Atom Count: 21
• Complexity: 395

Purity/Quality:

99% ^*data from raw suppliers

LINOGLIRIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1=NC(=NC2=CC=CC=C2)N3CCOCC3
• Isomeric SMILES: CN\1CCC/C1=N\C(=NC2=CC=CC=C2)N3CCOCC3
• Uses: Antidiabetic.

Technology Process of Linogliride

There total 4 articles about Linogliride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monophenylthiourea (103-85-5) → linogriride (75358-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / H₂O₂ / sodium molybdate / H₂O

2: 65 percent / acetonitrile

With dihydrogen peroxide; sodium molybdate; In water; acetonitrile;

Reference yield:

(N-phenylamino)iminomethanesulfonic acid (25343-52-6) → linogriride (75358-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / acetonitrile

In acetonitrile;

Reference yield:

N-phenyl-morpholine-4-carboximidic acid amide (75358-18-8) → linogriride (75358-37-1)

Guidance literature:

upstream raw materials:

N-phenyl-morpholine-4-carboximidic acid amide

(N-phenylamino)iminomethanesulfonic acid

monophenylthiourea

Refernces

• 1、 Maryanoff, Cynthia A.,Stanzione, Robin C.,Plampin, James N.. "REACTIONS OF OXIDIZED THIOUREAS WITH AMINE NUCLEOPHILES". . p. 221 - 232. Retrieved 2007/10/02.