cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

Base Information

Chemical Name:cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane
CAS No.:172912-08-2
Molecular Formula:C₄₆H₆₁N₅O₈SSi
Molecular Weight:872.171
Hs Code.:

cis-2-(tert-butyldiphenylsilyloxymethyl)-5-<N<sup>4</sup>-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

Synonyms:cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

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Chemical Property of cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

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Technology Process of cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

There total 9 articles about cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 172912-08-2
cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

2: 96 percent / diisobutylaluminium hydride / hexane; CH₂Cl₂ / 0.1 h / -78 °C

3: 8 percent / Zn / tetrahydrofuran / 0.75 h / Heating

4: 98 percent / NaOH / tetrahydrofuran / 2 h

5: BOP, Et₃N / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; zinc; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/0223-5234(96)88298-5

Reference yield:

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 172912-08-2
cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / diisobutylaluminium hydride / hexane; CH₂Cl₂ / 0.1 h / -78 °C

2: 8 percent / Zn / tetrahydrofuran / 0.75 h / Heating

3: 98 percent / NaOH / tetrahydrofuran / 2 h

4: BOP, Et₃N / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; zinc; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/0223-5234(96)88298-5

Reference yield:

: 72155-46-5
(3S,4S)-4-(N-tert-butoxycarbonyl)amino-3-hydroxy-5-phenylpentanoic acid ethyl ester

: 172912-08-2
cis-2-(tert-butyldiphenylsilyloxymethyl)-5-4-(Boc-AHPPA-1-oxo-6-aminopentyl)cytosin-1'-yl>-1,3-oxathiolane

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NaOH / tetrahydrofuran / 2 h

2: BOP, Et₃N / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0223-5234(96)88298-5