tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate
CAS No.:1448313-05-0
Molecular Formula:C₂₃H₂₈N₆O₃S
Molecular Weight:468.58
Hs Code.:

Synonyms:tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1448312-87-5
tert-butyl 4-(2-(3-amino-5-bromophenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1448313-05-0
tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1448313-05-0
tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 3 h / 80 °C / Cooling with ice

2.1: acetonitrile / 0.2 h / 100 °C / Microwave irradiation

2.2: 0.5 h / 150 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 100 °C / Microwave irradiation

4.1: ammonium chloride; iron / ethanol; water / 5 h / 70 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 1 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

: 1448312-86-4
tert-butyl 4-(2-(3-bromo-5-nitrophenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

: 1448313-05-0
tert-butyl 4-(2-(3-amino-5-(prop-1-en-2-yl)phenyl)-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / ethanol; water / 5 h / 70 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 1 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; ammonium chloride; In 1,4-dioxane; ethanol; water;