6307-83-1

Basic information

• Product Name: 3-Bromo-5-nitrobenzoic acid
• Synonyms: 3-BROMO-5-NITROBENZOIC ACID;3-Bromo-5-nitrobenzoic aci;3-Bromo-5-carboxynitrobenzene;Benzoic acid, 3-bromo-5-nitro-
• CAS NO: 6307-83-1
• Molecular Formula: C₇H₄BrNO₄
• Molecular Weight: 246.01
• Product Categories: blocks;Bromides;Carboxes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic;NULL
• Mol File: 6307-83-1.mol
• Article Data: 33

Chemical Properties

• Melting Point: 159-161°C
• Boiling Point: 376.8 °C at 760 mmHg
• Flash Point: 181.7 °C
• Appearance: white to slightly yellow crystalline needles
• Density: 1.892 g/cm³
• Vapor Pressure: 2.4E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.09±0.10(Predicted)
• BRN: 2051365
• CAS DataBase Reference: 3-Bromo-5-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-nitrobenzoic acid(6307-83-1)
• EPA Substance Registry System: 3-Bromo-5-nitrobenzoic acid(6307-83-1)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 36/37/38-50-22
• Safety Statements: 26-36/37/39-61-60-36/37-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 6307-83-1(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow crystalline needles

InChI:InChI=1/C7H4BrNO4/c8-5-1-4(7(10)11)2-6(3-5)9(12)13/h1-3H,(H,10,11)/p-1

Upstream product

• 121-92-6 3-nitrobenzoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 128-08-5 N-Bromosuccinimide 
• 610-29-7 2-nitroterephthalic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 136649-26-8 3-bromo-5-nitro-biphenyl 
• 64-19-7 acetic acid 
• 6307-87-5 methyl 3-bromo-5-nitrobenzoate 
• 355134-13-3 3-bromo-5-nitrobenzaldehyde 
• 618-84-8 3-amino-5-nitro-benzoic acid 

Downstream Products

• 60912-61-0 methyl 3-bromo-5-acetylaminobenzoate 
• 1639866-70-8 C₄₀H₅₅N₅O₉S 
• 1639866-72-0 3-amino-5-ethynylbenzoic acid 
• 1639866-71-9 3-ethynyl-5-nitrobenzoic acid 
• 1187832-11-6 20-ethynyl-19-deschloransamitocin P-3 
• 1639866-58-2 C₂₈H₃₄N₂O₆ 
• 1639866-59-3 C₃₁H₃₈N₂O₇ 
• 1639866-60-6 C₃₂H₄₀N₂O₇ 

Relevant articles and documents

Regioselective synthesis of carboxylic and fluoromethyl tetrazoles enabled by silver-catalyzed cycloaddition of diazoacetates and aryl diazonium salts

Here we present a dipolar [3 + 2] cycloaddition transformation of diazoacetates with arenediazonium salts under silver catalysis, thus offering a straightforward approach for the regioselective construction of carboxylic tetrazoles. Several merits are accompanied with this reaction including readily available starting reagents, broad coupling scope, high yields, and friendly reaction conditions. The synthetic value is further showcased by one-pot conversion of commercially available primary arylamines to tetrazoles and successful transformations of the cycloadducts into valuable 5-fluoromethyltetrazoles and an analogue of P2X3 receptor antagonist.

PYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided are a pyrimidine compound represented by Formula 1, a method of preparing the same, and a pharmaceutical use of the pyrimidine compound for the prevention or treatment of cancer.

Construction of Difluoromethylated Tetrazoles via Silver-Catalyzed Regioselective [3 + 2] Cycloadditions of Aryl Diazonium Salts

A silver-catalyzed regioselective [3 + 2] cycloaddition reaction of PhSO2CF2CHN2 with aryl diazonium salts is described. This protocol enables the straightforward construction of a novel class of difluoromethylated tetrazoles under mild conditions, tolerates a broad spectrum of functionalities, and is applicable to one-pot operation from commercially available aniline derivatives. The synthetic merit of this method is further demonstrated by the facile preparation of versatile difluoromethylated azoles, including a valuable HCF2-analogue of P2X3 receptor antagonist.