5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

Base Information

Chemical Name:5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol
CAS No.:935248-44-5
Molecular Formula:C₂₁H₃₈O₄Si
Molecular Weight:382.616
Hs Code.:

Synonyms:5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

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Chemical Property of 5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

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Technology Process of 5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

There total 7 articles about 5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 935248-43-4
(3S)-1-tert-butyldimethylsilyloxy-3-(4-methoxybenzyloxy)-2,2-dimethylpent-4-ene

: 935248-44-5
5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

Guidance literature:: (3S)-1-tert-butyldimethylsilyloxy-3-(4-methoxybenzyloxy)-2,2-dimethylpent-4-ene; With dimeric 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; at 20 ℃;

With dihydrogen peroxide; sodium acetate; In tetrahydrofuran; at 20 ℃; for 6h; Further stages.;
DOI:10.1021/ja067305j

Reference yield:

: 861119-09-7
(3S)-3-[(4-methoxyphenyl)methoxy]-2,2-dimethylpent-4-en-1-ol

: 935248-44-5
5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 9-BBN dimer / tetrahydrofuran / 20 °C

2.2: 93 percent / aq. H₂O₂; NaOAc / tetrahydrofuran / 6 h / 20 °C

With triethylamine; dimeric 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja067305j

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 935248-44-5
5-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4-dimethyl-pentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 9-BBN dimer / tetrahydrofuran / 20 °C

2.2: 93 percent / aq. H₂O₂; NaOAc / tetrahydrofuran / 6 h / 20 °C

With triethylamine; dimeric 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja067305j