(R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Base Information

Chemical Name:(R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride
CAS No.:1181690-30-1
Molecular Formula:C₂₆H₃₂N₂O*ClH
Molecular Weight:425.014
Hs Code.:

Synonyms:(R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

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Chemical Property of (R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

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Technology Process of (R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

There total 5 articles about (R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181690-12-9
(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1181690-30-1
(R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Guidance literature:: (R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline; cyclopropanecarboxylic acid chloride; With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

With hydrogenchloride; In diethyl ether;

Reference yield:

: (R)-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenylboronic Acid

: 1181690-30-1
(R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; benzene / 6 h / Reflux

2: triethylamine / dichloromethane / 0.33 h / 20 °C

With sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; benzene; 1: Suzuki Coupling;

Reference yield:

: 849519-42-2
(R)-1-[2-(4-bromo-phenyl)-ethyl]-2-methyl-pyrrolidine

: 1181690-30-1
(R)-cyclopropyl(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 - -70 °C / Inert atmosphere

1.2: 1.5 h / -65 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; benzene / 6 h / Reflux

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C

With n-butyllithium; sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; benzene; 2.1: Suzuki Coupling;