(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1181690-12-9
Molecular Formula:C₂₂H₂₈N₂
Molecular Weight:320.478
Hs Code.:

Synonyms:(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about (R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenylboronic Acid

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181690-12-9
(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In ethanol; water; benzene; for 6h; Reflux;

Reference yield:

: 114369-15-2
2-(4-bromophenyl)ethyl methanesulfonate

: 1181690-12-9
(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile; water / 71 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - -70 °C / Inert atmosphere

2.2: -65 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; benzene; ethanol / 6 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethanol; hexane; water; acetonitrile; benzene;

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1181690-12-9
(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine / toluene / 2 h / 100 °C / Inert atmosphere

2: sodium carbonate / palladium 10% on activated carbon / methanol; water / 5 h / 50 - 80 °C

With potassium acetate; sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; triphenylphosphine; In methanol; water; toluene; 1: Suzuki Coupling / 2: Suzuki Coupling;