N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

Base Information

Chemical Name:N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine
CAS No.:128563-29-1
Molecular Formula:C₂₇H₂₉N₅O₄
Molecular Weight:487.558
Hs Code.:

Synonyms:N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

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Chemical Property of N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

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Technology Process of N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

There total 3 articles about N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: Acetic acid (3aR,4R,6R,6aR)-6-{5-[1-(benzyl-phenyl-amino)-eth-(E)-ylideneamino]-4-cyano-imidazol-1-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

: 128563-29-1
N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

Guidance literature:: With ammonia; In methanol;
DOI:10.1139/v92-166

Reference yield:

: 758640-21-0,103-32-2
N-Benzylaniline

: 128563-29-1
N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 42 h / Ambient temperature

2: 29 percent / phosphoryl chloride / acetonitrile / 48 h

3: 94 percent / ammonia / methanol

With ammonia; triethylamine; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1139/v92-166

Reference yield:

: 6840-29-5
N-phenyl-N-benzylacetamide

: 128563-29-1
N-Benzyl-N'-[5-cyano-3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3H-imidazol-4-yl]-N-phenyl-acetamidine

Guidance literature:: Multi-step reaction with 2 steps

1: 29 percent / phosphoryl chloride / acetonitrile / 48 h

2: 94 percent / ammonia / methanol

With ammonia; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1139/v92-166