benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

Base Information

Chemical Name:benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate
CAS No.:1416956-68-7
Molecular Formula:C₃₃H₅₂F₂O₆
Molecular Weight:582.769
Hs Code.:

Synonyms:benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

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Chemical Property of benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

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Technology Process of benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

There total 7 articles about benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-6-methyl-3-hydroxyoctyl)-5-hydroxy-3-(2-tetrahydropyranyloxy)cyclopentyl]heptanoic acid

: 100-39-0
benzyl bromide

: 1416956-68-7
benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 13.5h;

Reference yield:

: methyl 7-[(1R,2R,3R,5S)-5-acetoxy-2-((E)-(6S)-4,4-difluoro-6-methyl-3-oxo-1-octenyl)-3-(2-tetrahydropyranyloxy)cyclopentyl]heptanate

: 1416956-68-7
benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 20 °C / 760.05 Torr

2.1: sodium tetrahydroborate; methanol / 0.58 h / -20 °C

3.1: sodium hydroxide; water / ethanol / 3.5 h / 20 °C / Cooling with ice

3.2: pH 3 - 4 / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 13.5 h / 20 °C

With methanol; sodium tetrahydroborate; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; 5%-palladium/activated carbon; In ethanol; ethyl acetate; acetonitrile;

Reference yield:

: 61302-48-5
methyl 7-((1R,2R,3R,5S)-5-acetoxy-2-formyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoate

: 1416956-68-7
benzyl 7-[(1R,2R,3R,5S)-2-((6S)-4,4-difluoro-3-hydroxy-6-methyloctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl]heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide monohydrate / tert-butyl methyl ether / 1 h / 20 °C

1.2: 31 h / 53 °C

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 20 °C / 760.05 Torr

3.1: sodium tetrahydroborate; methanol / 0.58 h / -20 °C

4.1: sodium hydroxide; water / ethanol / 3.5 h / 20 °C / Cooling with ice

4.2: pH 3 - 4 / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 13.5 h / 20 °C

With methanol; sodium tetrahydroborate; lithium hydroxide monohydrate; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; 5%-palladium/activated carbon; In ethanol; tert-butyl methyl ether; ethyl acetate; acetonitrile;