5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Base Information

Chemical Name:5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one
CAS No.:1398608-97-3
Molecular Formula:C₂₅H₁₈F₉N₃O₅S
Molecular Weight:643.487
Hs Code.:

5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Synonyms:5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Suppliers and Price of 5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

There total 13 articles about 5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 2516-97-4
2-(methylsulfonyl)acetic acid

: 5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)spiro[azetidine-3,1'-isoindolin]-3'-one hydrochloride

: 1398608-97-3
5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Guidance literature:: 2-(methylsulfonyl)acetic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)spiro[azetidine-3,1'-isoindolin]-3'-one hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: 1398608-97-3
5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: tetra-N-butylammonium tribromide / ethanol / 48 h / 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 36 h / Reflux

3.2: 0.25 h / pH Ca_.5 - Ca_.7

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1.5 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: toluene / 1 h / 90 °C

7.1: tert.-butyl lithium / tetrahydrofuran / 0 h / -78 - 0 °C

8.1: ammonium formate; palladium 10% on activated carbon / ethanol / 1 h / Reflux; Inert atmosphere

9.1: hydroxylamine hydrochloride / water; ethanol / 1 h / 50 °C

10.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 50 °C

10.2: 18 h / 20 °C

11.1: hydrogenchloride / methanol / 6 h / 65 °C

12.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C

12.2: 18 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; sodium azide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; palladium 10% on activated carbon; hydroxylamine hydrochloride; water; tert.-butyl lithium; ammonium formate; tetra-N-butylammonium tribromide; potassium hexamethylsilazane; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1357614-76-6
1-benzhydryl-3-(2-bromo-4-(diethoxymethyl)phenyl)azetidine-3-carbonitrile

: 1398608-97-3
5'-(5-(3,5-bis(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-(2-(methylsulfonyl)acetyl)spiro[azetidine-3,1'-isoindolin]-3'-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / ethanol / 36 h / Reflux

1.2: 0.25 h / pH Ca_.5 - Ca_.7

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1.5 h / 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: toluene / 1 h / 90 °C

5.1: tert.-butyl lithium / tetrahydrofuran / 0 h / -78 - 0 °C

6.1: ammonium formate; palladium 10% on activated carbon / ethanol / 1 h / Reflux; Inert atmosphere

7.1: hydroxylamine hydrochloride / water; ethanol / 1 h / 50 °C

8.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 50 °C

8.2: 18 h / 20 °C

9.1: hydrogenchloride / methanol / 6 h / 65 °C

10.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 °C

10.2: 18 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; sodium azide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; palladium 10% on activated carbon; hydroxylamine hydrochloride; water; tert.-butyl lithium; ammonium formate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;