methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate

Base Information

• Chemical Name: methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate
• CAS No.: 859828-48-1
• Molecular Formula: C₁₁H₁₁F₃O₅S
• Molecular Weight: 312.267
• Mol file: 859828-48-1.mol

Synonyms:methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate

Chemical Property of methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate

There total 3 articles about methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + methyl 2-(4-hydroxyphenyl)propanoate (65784-33-0) → methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate (859828-48-1)

Guidance literature:

methyl 2-(4-hydroxyphenyl)propanoate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 ℃; for 0.5h;

trifluoromethylsulfonic anhydride; In dichloromethane; at -15 ℃; for 1h;

DOI:10.1021/jm049082i

Reference yield:

2-(4-Hydroxy-phenyl)-propionic acid (938-96-5) → methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate (859828-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 51.6 g / H₂SO₄ / 20 °C

2.1: iPr₂NEt / CH₂Cl₂ / 0.5 h / -15 °C

2.2: CH₂Cl₂ / 1 h / -15 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm049082i

Reference yield:

→ methyl 2-{4-(trifluoromethanesulfonyloxy)phenyl}propanoate (859828-48-1)

Guidance literature:

upstream raw materials:

trifluoromethylsulfonic anhydride

methyl 2-(4-hydroxyphenyl)propanoate

2-(4-Hydroxy-phenyl)-propionic acid

Downstream raw materials:

methyl 2-[4-(cyclohexylmethyl)phenyl]propanoate

methyl 2-[4-(cyclohexyl)phenyl]propanoate

α-(p-cyclohexylphenyl)-propionic acid

2-(4'-<2-methyl-1-propenyl>phenyl)propanoic acid