4-toluenesulfonyl-penta(alpha-aminoisobutyryl)methyl ester

Base Information

Chemical Name:4-toluenesulfonyl-penta(alpha-aminoisobutyryl)methyl ester
CAS No.:69555-87-9
Molecular Formula:C₂₈H₄₅N₅O₈S
Molecular Weight:611.76
Hs Code.:
Mol file:69555-87-9.mol

Synonyms:Alanine,2-methyl-N-[2-methyl-N-[2-methyl-N-[2-methyl-N-(2-methyl-N-p-tolylsulfonylalanyl)alanyl]alanyl]alanyl]-,methyl ester (6CI)

Suppliers and Price of 4-toluenesulfonyl-penta(alpha-aminoisobutyryl)methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 4-toluenesulfonyl-penta(alpha-aminoisobutyryl)methyl ester

Chemical Property:

Density:1.19g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-toluenesulfonyl-penta(alpha-aminoisobutyryl)methyl ester

There total 16 articles about 4-toluenesulfonyl-penta(alpha-aminoisobutyryl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 98-59-9
p-toluenesulfonyl chloride

: 2-(2-{2-[2-(2-amino-2-methyl-propionylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid methyl ester

: 69555-87-9
C₂₈H₄₅N₅O₈S

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/d0ce01267j

Reference yield: 20.0%

: 103504-07-0
2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

: 15028-41-8
methyl 2-aminoisobutyrate hydrochloride

: 69555-87-9
C₂₈H₄₅N₅O₈S

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/d0ce01267j

Reference yield:

: 7663-91-4
2-methyl-2-(toluene-4-sulfonylamino)propionic acid

: 69555-87-9
C₂₈H₄₅N₅O₈S

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

6: lithium hydroxide monohydrate / tetrahydrofuran; water / 50 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/d0ce01267j