Technology Process of N-[(1S,4R,5R,6S)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-3-hydroxymethyl-cyclohex-2-enyl]-4-methyl-benzenesulfonamide
There total 8 articles about N-[(1S,4R,5R,6S)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-3-hydroxymethyl-cyclohex-2-enyl]-4-methyl-benzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: n-butyllithium; bidentate phosphite ligand; trimethyltin acetate; palladium diacetate / tetrahydrofuran; hexane / 42 h / Heating
2: methanol; triethanolamine; sodium methylate; diisobutylaluminium hydride; Rochelle's salt
With
methanol; n-butyllithium; triethanolamine; bidentate phosphite ligand; trimethyltin acetate; sodium methylate; palladium diacetate; diisobutylaluminium hydride; Rochelle's salt;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja973081g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / Ambient temperature
2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / Ambient temperature
3: n-butyllithium; bidentate phosphite ligand; trimethyltin acetate; palladium diacetate / tetrahydrofuran; hexane / 42 h / Heating
4: methanol; triethanolamine; sodium methylate; diisobutylaluminium hydride; Rochelle's salt
With
methanol; dmap; n-butyllithium; triethanolamine; bidentate phosphite ligand; trimethyltin acetate; sodium methylate; palladium diacetate; diisobutylaluminium hydride; sodium hydrogencarbonate; Rochelle's salt; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja973081g
- Guidance literature:
-
Multi-step reaction with 6 steps
1: methylene blue / 120 h / 80 °C
2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / benzene / 9 h / Ambient temperature
3: dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / Ambient temperature
4: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / Ambient temperature
5: n-butyllithium; bidentate phosphite ligand; trimethyltin acetate; palladium diacetate / tetrahydrofuran; hexane / 42 h / Heating
6: methanol; triethanolamine; sodium methylate; diisobutylaluminium hydride; Rochelle's salt
With
methanol; dmap; n-butyllithium; triethanolamine; bidentate phosphite ligand; trimethyltin acetate; sodium methylate; methylene blue; palladium diacetate; diisobutylaluminium hydride; sodium hydrogencarbonate; Rochelle's salt; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane; benzene;
DOI:10.1021/ja973081g
