(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

Base Information

Chemical Name:(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid
CAS No.:654068-64-1
Molecular Formula:C₂₃H₃₂Cl₂N₂O₇
Molecular Weight:519.422
Hs Code.:

Synonyms:(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

Chemical Property:

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Technology Process of (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

There total 1 articles about (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 654068-60-7
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

: 654068-64-1
(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; for 2h;
DOI:10.1021/jm030278c

Reference yield:

: 178977-57-6
tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate

: 654068-64-1
(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

: 654068-68-5
tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-(2E,7E)-dienoate

Guidance literature:: (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid; With dmap; 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 2h;

tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm030278c

Reference yield:

: 654068-64-1
(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

: 654068-72-1
10-(3',4'-dichlorobenzyl)demethoxybenzyldesepoxycryptophycin-24

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trichlorobenzoyl chloride; DIEA; DMAP / tetrahydrofuran / 2 h

1.2: 0.15 g / tetrahydrofuran / 2 h / 20 °C

2.1: CH₂Cl₂ / 2 h / 20 °C

3.1: 0.049 g / HBTU; DIEA / acetonitrile / 3 h / 20 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm030278c