benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Base Information

Chemical Name:benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate
CAS No.:654068-60-7
Molecular Formula:C₃₀H₃₈Cl₂N₂O₇
Molecular Weight:609.547
Hs Code.:

Synonyms:benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

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Chemical Property of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Chemical Property:

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Technology Process of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

There total 1 articles about benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114873-13-1,80741-39-5
N-Boc-D-3,4-dichlorophenylalanine

: (S)-2-(3-Amino-propionyloxy)-4-methyl-pentanoic acid benzyl ester; compound with trifluoro-acetic acid

: 654068-60-7
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 16.5h;
DOI:10.1021/jm030278c

Reference yield:

: 654068-60-7
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

: 654068-64-1
(2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoic acid

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; for 2h;
DOI:10.1021/jm030278c

Reference yield:

: 654068-60-7
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3,4-dichlorophenyl)propionylamino]propionyloxy]-4-methylpentanoate

: 654068-72-1
10-(3',4'-dichlorobenzyl)demethoxybenzyldesepoxycryptophycin-24

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / Pd(OH)2 / ethyl acetate / 2 h

2.1: 2,4,6-trichlorobenzoyl chloride; DIEA; DMAP / tetrahydrofuran / 2 h

2.2: 0.15 g / tetrahydrofuran / 2 h / 20 °C

3.1: CH₂Cl₂ / 2 h / 20 °C

4.1: 0.049 g / HBTU; DIEA / acetonitrile / 3 h / 20 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm030278c