2-(2-fluoroethoxy)phenyl azide

Base Information

Chemical Name:2-(2-fluoroethoxy)phenyl azide
CAS No.:1609428-91-2
Molecular Formula:C₈H₈FN₃O
Molecular Weight:181.169
Hs Code.:

Synonyms:2-(2-fluoroethoxy)phenyl azide

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Chemical Property of 2-(2-fluoroethoxy)phenyl azide

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Technology Process of 2-(2-fluoroethoxy)phenyl azide

There total 4 articles about 2-(2-fluoroethoxy)phenyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 1547-11-1
2-(2-fluoroethoxy)aniline

: 1609428-91-2
2-(2-fluoroethoxy)phenyl azide

Guidance literature:: 2-(2-fluoroethoxy)aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h; Inert atmosphere;

With sodium azide; sodium carbonate; In water; at 0 - 20 ℃; for 2.5h; pH=7 -Ca. 8; Inert atmosphere;
DOI:10.1021/jm5001453

Reference yield:

: 186663-74-1
tert-butyl (2-hydroxyphenyl)carbamate

: 1609428-91-2
2-(2-fluoroethoxy)phenyl azide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 4 h / Reflux; Inert atmosphere

2.1: hydrogenchloride / water; ethyl acetate / 2 h / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

3.2: 2.5 h / 0 - 20 °C / pH 7 -Ca_. 8 / Inert atmosphere

With hydrogenchloride; sodium hydride; sodium nitrite; In tetrahydrofuran; water; ethyl acetate; mineral oil;
DOI:10.1021/jm5001453

Reference yield:

: 1609428-88-7
tert-butyl (2-(2-fluoroethoxy)phenyl)carbamate

: 1609428-91-2
2-(2-fluoroethoxy)phenyl azide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; ethyl acetate / 2 h / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C / Inert atmosphere

2.2: 2.5 h / 0 - 20 °C / pH 7 -Ca_. 8 / Inert atmosphere

With hydrogenchloride; sodium nitrite; In water; ethyl acetate;
DOI:10.1021/jm5001453