1547-11-1

Basic information

• Product Name: 2-(2-FLUORO-ETHOXY)-PHENYLAMINE
• Synonyms: 2-(2-FLUORO-ETHOXY)-PHENYLAMINE;2-(2-fluoroethoxy)aniline
• CAS NO: 1547-11-1
• Molecular Formula: C₈H₁₀FNO
• Molecular Weight: 155.17
• Mol File: 1547-11-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 254.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.127±0.06 g/cm3(Predicted)
• PKA: 4.19±0.10(Predicted)
• CAS DataBase Reference: 2-(2-FLUORO-ETHOXY)-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUORO-ETHOXY)-PHENYLAMINE(1547-11-1)
• EPA Substance Registry System: 2-(2-FLUORO-ETHOXY)-PHENYLAMINE(1547-11-1)

Safety Data

• Hazardous Substances Data: 1547-11-1(Hazardous Substances Data)

Usage

Composition

Phenyl ring, 2-fluoro-ethoxy group, amino group

Type

Aromatic amine

Usage

Building block in organic synthesis

Applications

Preparation of pharmaceuticals, agrochemicals, and specialty chemicals

Role

Reagent in chemical reactions, precursor for complex organic molecules synthesis

Structural Feature

Presence of the fluoro-ethoxy group

Importance

Valuable intermediate for diverse functionalized compounds

Field

Organic chemistry and chemical research

Upstream product

• 132836-98-7 1-bromo-2-(2-fluoroethoxy)benzene 
• 95-56-7 2-hydroxybromobenzene 
• 95-55-6 2-amino-phenol 
• 1609428-88-7 tert-butyl (2-(2-fluoroethoxy)phenyl)carbamate 
• 186663-74-1 tert-butyl (2-hydroxyphenyl)carbamate 
• 88-75-5 2-hydroxynitrobenzene 
• 132838-18-7 1-(2-fluoroethoxy)-2-nitrobenzene 

Downstream Products

• 1335465-70-7 ethyl 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-1-(2-methoxy-2-oxoethyl)ureido)methyl)-indole-2-carboxylate 
• 1335465-80-9 ethyl 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylate 
• 1335465-88-7 4,6-dichloro-3-((3-(2-(2-fluoroethoxy)phenyl)-2,4-dioxoimidazolidin-1-yl)methyl)-indole-2-carboxylic acid 
• 1609428-91-2 2-(2-fluoroethoxy)phenyl azide 
• 1609428-93-4 ethyl 1-(2-(2-fluoroethoxy) phenyl)-1H-1,2,3-triazole-4-carboxylate 
• 1609428-96-7 1-(2-(2-fluoroethoxy)phenyl)-1H-1,2,3-triazole-4-carboxylic acid 
• 1609428-39-8 N-(4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl)-1-(2-(2-fluoroethoxy)phenyl)-1H-1,2,3-triazole-4-carboxamide 

Relevant articles and documents

P2X7 MODULATORS

The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

Synthesis, labelling and evaluation of hydantoin-substituted indole carboxylic acids as potential ligands for positron emission tomography imaging of the glycine binding site of the N-methyl- d -aspartate receptor

The N-methyl- d-aspartate (NMDA) receptor as a type of ionotropic glutamatergic receptors is essential for physiological processes such as learning, memory and synaptic plasticity. A glutamate-induced overactivation of these receptors, accompanied by increased intracellular calcium concentration, causes cell injury and leads to a large number of acute or chronic neurological disorders, such as stroke, trauma, Parkinson's disease and Alzheimer's disease. In an attempt to visualise the glutamatergic neurotransmission in vivo with positron emission tomography, novel fluoroethoxy- and methoxy-substituted reference compounds based on the lead structure of a hydantoin-substituted indole-2-carboxylic acid were synthesised. The affinities towards the glycine binding site of the NMDA receptor showed Ki values between 322 and 11 nM and the lipophilicities ranged from logD values of 1.51 to 2.53. On the basis of these results, precursor compounds were synthesised containing a phenolic hydroxy moiety to obtain the radiolabelled ligands through an alkylation reaction. Radiosynthesis was achieved by labelling the precursor ethyl 4,6-dichloro-3-((3-(4-hydroxyphenyl)-2,4-dioxoimidazolidin-1-yl)methyl)- indole-2-carboxylate with 2-[18F]fluoroethyl tosylate or [ 11C]methyl iodide and subsequent cleavage of the ethyl ester moiety. This gave the final products in overall decay-corrected radiochemical yields of 5-7% and 6-9% and specific activities of 24-67 GBq/μmol and 8-26 GBq/μmol, respectively. Copyright