<1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

Base Information

Chemical Name:<1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril
CAS No.:158611-45-1
Molecular Formula:C₂₀H₁₅N₃O₂
Molecular Weight:329.358
Hs Code.:

Synonyms:<1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

Suppliers and Price of <1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

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Technology Process of <1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

There total 4 articles about <1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 157977-23-6
1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-carbaldehyd

: 109-77-3
malononitrile

: 158611-45-1
<1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

Guidance literature:: With 3-amino propanoic acid; In ethanol; for 24h; Ambient temperature;
DOI:10.1002/ardp.19943270804

Reference yield:

: 62655-56-5
2-(4'-methoxy-phenyl)-6-methoxy-indole

: 158611-45-1
<1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 80percent NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, 0 deg C, 30 min; r.t., 2 h

2: 82 percent / POCl₃ / 1.5 h / 35 °C

3: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

4: 79 percent / β-alanin / ethanol / 24 h / Ambient temperature

With boron tribromide; sodium hydride; 3-amino propanoic acid; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1002/ardp.19943270804

Reference yield:

: 91444-19-8
1-ethyl-2-(4-methoxyphenyl)-6-methoxyindole

: 158611-45-1
<1-Ethyl-6-hydroxy-2-(4-hydroxyphenyl)-indol-3-yl>-methylidenmalonsaeuredinitril

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / POCl₃ / 1.5 h / 35 °C

2: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: 79 percent / β-alanin / ethanol / 24 h / Ambient temperature

With boron tribromide; 3-amino propanoic acid; trichlorophosphate; In ethanol; dichloromethane;
DOI:10.1002/ardp.19943270804