(11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione

Base Information

• Chemical Name: (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione
• CAS No.: 923973-12-0
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.364
• Mol file: 923973-12-0.mol

Synonyms:(11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione

Chemical Property of (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

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Technology Process of (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione

There total 6 articles about (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C16H20INO3 (1242415-74-2) + benzylamine (100-46-9) → (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione (923973-12-0)

Guidance literature:

C₁₆H₂₀INO₃; benzylamine; With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 24h;

With hydrogenchloride; In water; dimethyl sulfoxide; at 110 ℃; for 5h;

DOI:10.1016/j.tet.2010.04.127

Reference yield: 75.0%

benzyl bromide (100-39-0) + (S)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione (24919-40-2,60269-66-1,18877-34-4) → (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione (923973-12-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 3h; Reflux;

DOI:10.1002/jhet.1775

Reference yield: 52.0%

(S)-methyl 1-(2-Bromobenzoyl)pyrrolidine-2-carboxylate (155394-21-1) + benzylamine (100-46-9) → (11aS)-10-benzyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-(10H,11aH)-dione (923973-12-0) + C26H27N3O2 (1242415-71-9)

Guidance literature:

With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 ℃; for 24h;

DOI:10.1016/j.tet.2010.04.127

upstream raw materials:

C₁₆H₂₀INO₃

benzylamine

(S)-methyl 1-(2-Bromobenzoyl)pyrrolidine-2-carboxylate

2-Iodobenzoic acid