(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Name:(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234619-36-3
Molecular Formula:C₃₀H₁₈F₃N₇O₄S
Molecular Weight:629.579
Hs Code.:

(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Synonyms:(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

There total 15 articles about (7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1234619-35-2
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

: 1234619-36-3
(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: (7R)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: With chiral silica gel phase based on the selector poly(N-methacryloyl-L-isoleucine-3-pentylamide); In 2-Methylpentane; ethyl acetate; at 24 ℃; Purification / work up; Resolution of racemate;

Reference yield: 86.0%

: 1234619-35-2
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

: 1234619-36-3
(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: With Chiral Column; In 2-Methylpentane; ethyl acetate; for 24h; Resolution of racemate;
DOI:10.1002/cmdc.201500269

Reference yield:

: 1234620-63-3
4-(2-cyano-3-oxobut-1-en-1-yl)-3-(methylsulfonyl)benzonitrile

: 1234619-36-3
(7S)-7-[4-Cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / 20 °C / Inert atmosphere; Molecular sieve

2.1: pyridine; toluene-4-sulfonic acid / toluene / 1 h / Reflux

3.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

4.1: copper diacetate; triethylamine; pyridine / dichloromethane / 12 h / 20 °C / Molecular sieve; Inert atmosphere

4.2: 72 h / 20 °C / Inert atmosphere

5.1: Chiral Column / 2-Methylpentane; ethyl acetate / 24 h / Resolution of racemate

With pyridine; copper diacetate; toluene-4-sulfonic acid; triethylamine; rac-Pro-OH; In 2-Methylpentane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 4.1: |Chan-Lam Coupling / 4.2: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201500269