(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

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Chemical Name:(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234619-35-2
Molecular Formula:C₃₀H₁₈F₃N₇O₄S
Molecular Weight:629.579
Hs Code.:

(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

Synonyms:(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

There total 9 articles about (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.1%

: 1234620-66-6
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1234619-35-2
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile; (meta-(trifluoromethyl)phenyl)boronic acid; With pyridine; copper diacetate; triethylamine; In dichloromethane; for 12h; Inert atmosphere; Molecular sieve;

With 2,6-dimethylpyridine; In dichloromethane; for 84h; Inert atmosphere;

With 2,6-dimethylpyridine; copper diacetate; copper; In dichloromethane; for 120h;

Reference yield:

: 1234620-64-4
(rac)-2-amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1234619-35-2
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

2.1: triethylamine; pyridine; copper diacetate / dichloromethane / 12 h / Inert atmosphere; Molecular sieve

2.2: 84 h / Inert atmosphere

2.3: 120 h

With pyridine; copper diacetate; triethylamine; In dichloromethane; toluene;

Reference yield:

: 1234620-63-3
4-(2-cyano-3-oxobut-1-en-1-yl)-3-(methylsulfonyl)benzonitrile

: 1234619-35-2
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4-[3-(trifluoromethyl)phenyl]-4,7-dihydro[1,2,4]triazolo-[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

2.1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

3.1: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

4.1: triethylamine; pyridine; copper diacetate / dichloromethane / 12 h / Inert atmosphere; Molecular sieve

4.2: 84 h / Inert atmosphere

4.3: 120 h

With pyridine; copper diacetate; toluene-4-sulfonic acid; triethylamine; rac-Pro-OH; In dichloromethane; N,N-dimethyl-formamide; toluene;