2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester

Base Information

• Chemical Name: 2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester
• CAS No.: 885599-44-0
• Molecular Formula: C₂₂H₂₅BrO₅
• Molecular Weight: 449.341
• Mol file: 885599-44-0.mol

Synonyms:2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester

Chemical Property of 2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester

There total 1 articles about 2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

1-(benzyloxy)-3,5-dibromobenzene (128924-01-6) → 2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester (885599-44-0)

Guidance literature:

tert-Butyl ethyl malonate; With sodium hydride; In 1,4-dioxane; at 20 ℃; for 1h;

1-(benzyloxy)-3,5-dibromobenzene; copper(I) bromide; In 1,4-dioxane; for 5h; Heating / reflux;

With hydrogenchloride; water; In 1,4-dioxane;

Reference yield: 97.0%

2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester (885599-44-0) → (3-benzyloxy-5-bromo-phenyl-)acetic acid ethyl ester (885599-43-9)

Guidance literature:

With water; acetic acid; for 12h; Heating / reflux;

upstream raw materials:

1-(benzyloxy)-3,5-dibromobenzene

Downstream raw materials:

(3-benzyloxy-5-bromo-phenyl-)acetic acid ethyl ester