1-(Benzyloxy)-3,5-dibromobenzene

Base Information

• Chemical Name: 1-(Benzyloxy)-3,5-dibromobenzene
• CAS No.: 128924-01-6
• Molecular Formula: C13H10Br2O
• Molecular Weight: 342.03
• Hs Code.: 2909309090
• ChEMBL ID: CHEMBL4101853
• DSSTox Substance ID: DTXSID201289063
• Mol file: 128924-01-6.mol

Synonyms:1-(Benzyloxy)-3,5-dibromobenzene;128924-01-6;3,5-dibromo-1-benzyloxybenzene;1,3-dibromo-5-phenylmethoxybenzene;1-benzyloxy-3,5-dibromobenzene;1-Benzyloxy-3,5-dibromo-benzene;SCHEMBL308991;1,3-Dibromo-5-benzyloxybenzene;CHEMBL4101853;CROMNVSVLZKBEF-UHFFFAOYSA-N;DTXSID201289063;MFCD17011975;1,3-Dibromo-5-(phenylmethoxy)benzene;AKOS022181515;AT10429;Benzene, 1,3-dibromo-5-(phenylmethoxy)-;CS-0148200;A888945

Chemical Property of 1-(Benzyloxy)-3,5-dibromobenzene

Chemical Property:

• PSA: 9.23000
• LogP: 4.79060
• Storage Temp.: 2-8°C
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 341.90779
• Heavy Atom Count: 16
• Complexity: 194

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dibromo-1-Benzyloxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC(=CC(=C2)Br)Br

Technology Process of 1-(Benzyloxy)-3,5-dibromobenzene

There total 6 articles about 1-(Benzyloxy)-3,5-dibromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

3,5-dibromophenol (626-41-5) + benzyl bromide (100-39-0) → 1-(benzyloxy)-3,5-dibromobenzene (128924-01-6)

Guidance literature:

3,5-dibromophenol; With potassium carbonate; In acetone; at 20 ℃;

benzyl bromide; In acetone; at 20 ℃; for 16h;

DOI:10.1021/jo1000109

Reference yield: 92.0%

3,5-dibromonitrobenzene (6311-60-0) + benzyl alcohol (100-51-6,185532-71-2) → 1-(benzyloxy)-3,5-dibromobenzene (128924-01-6)

Guidance literature:

With potassium hydroxide; oxygen; tetrabutylammomium bromide; In tetramethylurea; at 20 ℃; for 7h;

Reference yield: 77.0%

1,3,5-trisbromobenzene (626-39-1) + benzyl alcohol (100-51-6,185532-71-2) → 1-(benzyloxy)-3,5-dibromobenzene (128924-01-6)

Guidance literature:

benzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; at 55 ℃; for 0.166667h;

1,3,5-trisbromobenzene; In N,N-dimethyl-formamide; at 55 - 120 ℃; for 4h;

upstream raw materials:

3,5-dibromonitrobenzene

benzyl alcohol

1,3-dibromo-5-fluorobenzene

1,3,5-trisbromobenzene

Downstream raw materials:

2-(3-benzyloxy-5-bromo-phenyl)-malonic acid tert-butyl ester ethyl ester

3,5-dibromophenol

(3-benzyloxy-5-bromo-phenyl)-pyridin-3-yl-amine

[3-benzyloxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-pyridin-3-yl-amine