2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine
CAS No.:133052-12-7
Molecular Formula:C₄₅H₄₁N₇
Molecular Weight:679.867
Hs Code.:

Synonyms:2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

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Chemical Property of 2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

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Technology Process of 2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

There total 9 articles about 2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22934-23-2
2-amino-4,6-dimethyl-3-nitropyridine

: 133052-12-7
2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 760 Torr

2: polyphosphoric acid / 80 - 90 °C

3: 1.) NaH / 1.) DMF, 25 deg C, 20 min

With PPA; hydrogen; sodium hydride; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00113a035

Reference yield:

: 106-38-7
para-bromotoluene

: 133052-12-7
2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

2: 1.) Me₃SnN₃, 2.) aq. HCl / 1.) toluene, reflux, 24 h, 2.) 25 deg C

3: Et₃N / CH₂Cl₂ / 1.5 h / Heating

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 2 h / Heating

5: 1.) NaH / 1.) DMF, 25 deg C, 20 min

With hydrogenchloride; N-Bromosuccinimide; sodium hydride; azidotrimethyltin; triethylamine; dibenzoyl peroxide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00113a035

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 133052-12-7
2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

2: 1.) Me₃SnN₃, 2.) aq. HCl / 1.) toluene, reflux, 24 h, 2.) 25 deg C

3: Et₃N / CH₂Cl₂ / 1.5 h / Heating

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 2 h / Heating

5: 1.) NaH / 1.) DMF, 25 deg C, 20 min

With hydrogenchloride; N-Bromosuccinimide; sodium hydride; azidotrimethyltin; triethylamine; dibenzoyl peroxide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00113a035