22934-23-2

Basic information

• Product Name: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE
• Synonyms: 4,6-DIMETHYL-3-NITROPYRIDIN-2-AMINE;4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE
• CAS NO: 22934-23-2
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.17
• Mol File: 22934-23-2.mol

Chemical Properties

• Melting Point: 164 °C
• Boiling Point: 318.4°Cat760mmHg
• Flash Point: 146.4°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 0.000362mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• PKA: 3.15±0.50(Predicted)
• CAS DataBase Reference: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE(22934-23-2)
• EPA Substance Registry System: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE(22934-23-2)

Safety Data

• Hazardous Substances Data: 22934-23-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE is utilized as an intermediate in the production of agrochemicals, playing a crucial role in the creation of substances that protect crops and enhance agricultural productivity.
Used in Organic Compounds Production:
4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE is used as a building block in the production of organic compounds, highlighting its versatility and importance in organic chemistry.
Used in Dyes and Pigments Manufacturing:
4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE is also used as a raw material in the manufacturing of dyes and pigments, where its chemical properties contribute to the color and stability of these products.
Used in Medicinal Chemistry Research:
4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE may have potential applications in the field of medicinal chemistry, serving as a valuable reagent for research and development of new therapeutic agents.
Used in Chemical Processes:
As a reagent in various chemical processes, 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE aids in facilitating reactions and improving the efficiency of chemical synthesis.

InChI:InChI=1/C7H9N3O2/c1-4-3-5(2)9-7(8)6(4)10(11)12/h3H,1-2H3,(H2,8,9)

Upstream product

• 13514-88-0 nitroacetamidine 
• 123-54-6 acetylacetone 
• 89853-68-9 (4,6-dimethyl-pyridin-2-yl)-nitro-amine 
• 1336-21-6 ammonium hydroxide 
• 5407-87-4 2-Amino-4,6-dimethylpyridine 
• 3102-33-8 trans-3-penten-2-one 
• 71090-35-2 1,1-diamino-2-nitroethene 
• 146580-30-5 2-Amino-1,4-dihydro-4,5-dimethyl-3-nitropyridin 

Downstream Products

• 133240-06-9 5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine 
• 133240-46-7 L-158,809 
• 133240-47-8 5,7-Dimethyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine 
• 133051-72-6 2-Butyl-5,7-dimethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine 
• 133052-12-7 2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine 
• 50850-16-3 2,3-diamino-4,6-dimethylpyridine 
• 90008-31-4 2,5-diamino-4,6-dimethyl-pyridine 
• 1197880-20-8 3-(4-bromobenzyl)-2-isopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine 
• 1198009-55-0 (E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine 
• 1197880-19-5 (E)-3-(4-((5,7-dimethyl-2-isopropyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol 
• 1197880-15-1 (E)-3-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol 
• 1197880-22-0 (E)-methyl 3-(4-((2-isopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate 
• 1197880-18-4 (E)-methyl 3-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate 
• 1197880-16-2 3-(4-bromobenzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

Innovative approaches to the imidazo[4,5-b]pyridine ring system. Development of an efficient process for industrial-scale production of a key intermediate for potent angiotensin II receptor antagonists

Two syntheses of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (3), an important intermediate for the synthesis of several potent angiotensin II antagonists, have been investigated. The first route involves conversion of 1,1-bis(methylthio)-2-nitroethene (17) to 2-ammo-4,6-dimethyl-3-nitropyridine (6); catalytic hydrogenation of 6 in propionic acid gave 3 in high yield. In the second synthesis, propionitrile is converted to imidate hydrochloride 15·HCl which is neutralised and reacted with aminoacetonitrile in the presence of acetylacetone to give 3 in 55% overall yield. The propionitrile route was scaled up to produce 3 in the pilot plant.

Process for preparing imidazopyridine derivatives

A process for preparing imidazopyridine derivatives of the general formula: STR1 wherein R1 is hydrogen or an alkyl group, and R2, R3 and R4 are identical or different and are hydrogen, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group or a halogen atom. In this process, a 2-amino-3-nitropyridine is hydrogenated in the presence of a hydrogenation catalyst and the hydrogenation product is condensed with a carboxylic acid simultaneously present in the reaction mixture to give the end product. The imidazopyridine derivatives are intermediates for the preparation of angiotensin II antagonists.

Polyfunctional pyridines from nitroacetamidine and β-diketones. A useful synthesis of substituted imidazo[4,5-b]pyridines and related compounds

Nitroacetamidine undergoes a useful cyclocondensation with β-diketones to produce substituted 2-amino-3-nitropyridines. Use of an acylpyruvate generates hitherto unreported 2-amino-3-nitropyridine-4-carboxylates. These may be converted easily to functionalized imidazo[4,5-b]pyridines and oxazolo[5,4-b]pyridines.

Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists

Substituted Imidazo-fused 6-membered heterocycles of structural formula: STR1 wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.

Angiotensin II antagonists incorporating a substituted thiophene or furan

There are disclosed substituted thiophene and furan derivatives of Formula I which are useful as angiotensin II antagonists. STR1

ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED PYRIDOIMIDAZOLYL RING

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. STR1

Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle

There are disclosed compounds, containing a pyridine, pyrazine or pyrimidine functionality on the lower ring of Formula I, which are useful as angiotensin II antagonists. STR1

SUBSTITUTED IMIDAZO-FUSED 6-MEMBERED HETEROCYCLCES AS ANGIOTENSIN II ANTAGONISTS

Substituted Imidazo-fused 6-membered heterocycles of structural formula: STR1 wherein A, B, C, and D are independently carbon atoms or nitrogren atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.

Nitroketenaminals, VII: Synthesis of substituted 2-amino-3-nitropyridines from 1,3-biselectrophiles and 2-nitroethen-1,1-diamine

The reaction of the enones 1a-f with the nitroketenaminal 2 leads to the 4,6-disubstituted 2-amino-1,4-dihydro-3-nitropyridines 3a-f. Compounds 3a-c,f are oxidized in low yields by air to the pyridines 4a-c,f.-5- and 6-substituted 2-amino-3-nitropyridines (9a,b and 11) can be prepared from 2, 8a,b, and 10, respectively.

ANGIOTENSIN II ANTAGONISTS INCORPORATING AN INDOLE OR DIHYDROINDOLE

There are disclosed substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists. STR1