1-mesityl-4-tosylpiperazine

Base Information

• Chemical Name: 1-mesityl-4-tosylpiperazine
• CAS No.: 100239-86-9
• Molecular Formula: C₂₀H₂₆N₂O₂S
• Molecular Weight: 358.505
• Mol file: 100239-86-9.mol

Synonyms:1-mesityl-4-tosylpiperazine

Chemical Property of 1-mesityl-4-tosylpiperazine

Chemical Property:

• Boiling Point: 523.9±60.0 °C(Predicted)
• Density: 1.174±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-mesityl-4-tosylpiperazine

There total 2 articles about 1-mesityl-4-tosylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trimethylaniline (88-05-1) + N,N-bis(2-bromoethyl)-4-methylbenzenesulfonamide (52601-82-8) → 1-mesityl-4-tosylpiperazine (100239-86-9)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 38h;

DOI:10.1021/ol400568u

Reference yield:

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide (16695-22-0) → 1-mesityl-4-tosylpiperazine (100239-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium bromide / acetone / 6 h / Reflux

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 38 h / 100 °C

With potassium carbonate; sodium iodide; lithium bromide; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol400568u

Reference yield:

1-mesityl-4-tosylpiperazine (100239-86-9) → 1-(2,4,6-trimethyl phenyl)piperazine (91904-13-1)

Guidance literature:

With sulfuric acid; at 120 ℃; for 3h;

DOI:10.1021/ol400568u

upstream raw materials:

N,N-bis(tosyloxyethyl)-p-toluenesulfonamide

2,4,6-trimethylaniline

N,N-bis(2-bromoethyl)-4-methylbenzenesulfonamide

Downstream raw materials:

1-(2,4,6-trimethyl phenyl)piperazine

tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

tert-butyl 4-mesitylpiperazine-1-carboxylate

Refernces