tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate
CAS No.:1429754-87-9
Molecular Formula:C₂₆H₃₃N₃O₄
Molecular Weight:451.566
Hs Code.:

Synonyms:tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

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Technology Process of tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

There total 3 articles about tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 102-96-5
(2-nitroethenyl)benzene

: 1121599-71-0
tert-butyl 4-mesitylpiperazine-1-carboxylate

: 1429754-87-9
tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

Guidance literature:: With dmap; iron(III) chloride; di-tert-butyl peroxide; In 1,2-dichloro-ethane; at 60 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol400568u

Reference yield:

: 100239-86-9
1-mesityl-4-tosylpiperazine

: 1429754-87-9
tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 3 h / 120 °C

2: dichloromethane / 3 h / 20 °C

3: iron(III) chloride; dmap; di-tert-butyl peroxide / 1,2-dichloro-ethane / 48 h / 60 °C / Inert atmosphere

With dmap; iron(III) chloride; di-tert-butyl peroxide; sulfuric acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol400568u

Reference yield:

: 91904-13-1
1-(2,4,6-trimethyl phenyl)piperazine

: 1429754-87-9
tert-butyl 4-mesityl-6-(2-nitro-1-phenylethyl)-3,4-dihydropyrazine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 20 °C

2: iron(III) chloride; dmap; di-tert-butyl peroxide / 1,2-dichloro-ethane / 48 h / 60 °C / Inert atmosphere

With dmap; iron(III) chloride; di-tert-butyl peroxide; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol400568u