carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

Base Information

Chemical Name:carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester
CAS No.:952527-71-8
Molecular Formula:C₁₃H₁₃NO₅
Molecular Weight:263.25
Hs Code.:

Synonyms:carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

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Chemical Property of carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

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Technology Process of carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

There total 3 articles about carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 33432-53-0
2-methyl-4-(4-nitrophenyl)but-3-yn-2-ol

: 79-22-1
methyl chloroformate

: 952527-71-8
carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

Guidance literature:: 2-methyl-4-(4-nitrophenyl)but-3-yn-2-ol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

methyl chloroformate; In tetrahydrofuran; at 0 ℃; for 12h; Further stages.;
DOI:10.1021/ol7018086

Reference yield:

: 115-19-5
2-methyl-but-3-yn-2-ol

: 952527-71-8
carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / Et₃N; CuI / PdCl₂(PPh₃)2 / tetrahydrofuran / 12 h / Heating

2.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 0 °C

2.2: 88 percent / tetrahydrofuran; various solvent(s) / 12 h / 0 °C

With copper(l) iodide; sodium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;
DOI:10.1021/ol7018086

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 952527-71-8
carbonic acid 1,1-dimethyl-3-(4-nitro-phenyl)-prop-2-ynyl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / Et₃N; CuI / PdCl₂(PPh₃)2 / tetrahydrofuran / 12 h / Heating

2.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 0 °C

2.2: 88 percent / tetrahydrofuran; various solvent(s) / 12 h / 0 °C

With copper(l) iodide; sodium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;
DOI:10.1021/ol7018086