(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

Base Information

Chemical Name:(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate
CAS No.:1207681-40-0
Molecular Formula:C₂HF₃O₂*C₁₉H₂₀N₂O₃S
Molecular Weight:470.469
Hs Code.:

Synonyms:(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

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Chemical Property of (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

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Technology Process of (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

There total 1 articles about (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105355-27-9,111025-46-8
Pioglitazone

: 76-05-1
trifluoroacetic acid

: 1207681-40-0
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

Guidance literature:: With CHIRALPAK AD-H (250 x 30 mm, 5μm); In ethanol; Resolution of racemate;

Reference yield: 47.0%

: 1207681-40-0
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

: 959687-65-1,111025-46-8
(R)-5-({p-[2-(5-ethyl-2-pyridyl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

Guidance literature:: With macroporous triethylammonium methylpolystyrene carbonate; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1207681-40-0
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione trifluoroacetate

: 1207681-45-5
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: macroporous triethylammonium methylpolystyrene carbonate / methanol / 2 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; In methanol;