Pioglitazone hydrochloride, (R)-

Base Information Edit

Chemical Name:Pioglitazone hydrochloride, (R)-
CAS No.:1207681-45-5
Molecular Formula:C₁₉H₂₀N₂O₃S*ClH
Molecular Weight:392.906
Hs Code.:
UNII:87XOE7NBH0
Mol file:1207681-45-5.mol

Synonyms:87XOE7NBH0;Pioglitazone hydrochloride, (R)-;UNII-87XOE7NBH0;(5R)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione hydrochloride (1:1);1207681-45-5;2,4-Thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, hydrochloride (1:1), (5R)-;SCHEMBL1162192;GHUUBYQTCDQWRA-UNTBIKODSA-N;(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride

Suppliers and Price of Pioglitazone hydrochloride, (R)-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pioglitazone hydrochloride, (R)- Edit

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:392.0961414
Heavy Atom Count:26
Complexity:466

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl
Isomeric SMILES:CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)C[C@@H]3C(=O)NC(=O)S3.Cl

Technology Process of Pioglitazone hydrochloride, (R)-

There total 13 articles about Pioglitazone hydrochloride, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (5R)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)-1,3-thiazolidine-2,4-dione O,O'-dibenzoyltartrate

: 1207681-45-5
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water; at 40 - 45 ℃; Inert atmosphere;

Reference yield:

: 1207681-56-8
thiocarbamic acid S-((R)-2-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl}-2-oxo-ethyl) ester

: 1207681-45-5
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride

Guidance literature:: thiocarbamic acid S-((R)-2-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-1-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl}-2-oxo-ethyl) ester; With water; In methanol; at 20 ℃; for 2.5h; Inert atmosphere;

With hydrogenchloride; In methanol; Inert atmosphere;

Reference yield:

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 1207681-45-5
(5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate / toluene / 113 h / 20 °C / Reflux; Inert atmosphere

3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / Inert atmosphere

3.2: pH 6 - 7 / Inert atmosphere

4.1: triethylamine; pivaloyl chloride / toluene / 22.5 h / 80 °C / Reflux; Inert atmosphere

5.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere

5.2: 1.83 h / -78 °C / Inert atmosphere

6.1: water / platinum tris(dimethylphosphine oxide) / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere

7.1: water / methanol / 2.5 h / 20 °C / Inert atmosphere

7.2: Inert atmosphere

With lithium hydroxide monohydrate; water; pivaloyl chloride; potassium carbonate; triethylamine; lithium diisopropyl amide; platinum tris(dimethylphosphine oxide); In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; dichloromethane; toluene;