5-hydroxy(²H₂)methyl-1,2,3-trimethoxybenzene

Base Information

• Chemical Name: 5-hydroxy(²H₂)methyl-1,2,3-trimethoxybenzene
• CAS No.: 478703-05-8
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 200.203
• Mol file: 478703-05-8.mol

Synonyms:5-hydroxy(²H₂)methyl-1,2,3-trimethoxybenzene

Chemical Property of 5-hydroxy(²H₂)methyl-1,2,3-trimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy(²H₂)methyl-1,2,3-trimethoxybenzene

There total 3 articles about 5-hydroxy(²H₂)methyl-1,2,3-trimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) → 5-hydroxy(2H2)methyl-1,2,3-trimethoxybenzene (478703-05-8)

Guidance literature:

With lithium aluminium deuteride; In diethyl ether; for 4h; Heating;

DOI:10.1002/jlcr.587

Reference yield:

Eudesmic acid (118-41-2) → 5-hydroxy(2H2)methyl-1,2,3-trimethoxybenzene (478703-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / conc. sulphuric acid / 5 h / Heating

2: 87 percent / LiAlD₄ / diethyl ether / 4 h / Heating

With lithium aluminium deuteride; sulfuric acid; In diethyl ether;

DOI:10.1002/jlcr.587

Reference yield:

ethyl 3,4,5-trimethoxybenzoate (6178-44-5) → 5-hydroxy(2H2)methyl-1,2,3-trimethoxybenzene (478703-05-8)

Guidance literature:

With sodium borodeuteride; lithium chloride; In tetrahydrofuran;

DOI:10.1021/acs.jafc.0c01956

upstream raw materials:

3,4,5-trimethoxybenzoic acid methyl ester

Eudesmic acid

ethyl 3,4,5-trimethoxybenzoate

Downstream raw materials:

3,4,5-trimethoxybenzaldehyde-α-d₁

2,6-dimethoxy-p-quinone

3,4,5-trimethoxy-benzaldehyde

C₉H₉⁽²⁾H₃O₄

Refernces

• 1、 Hamamura, Kimio,Yamagishi, Yoji,Kijima, Shizumasa,Suzuki, Takeshi,Mori, Yutaka,Nakamura, Tetsuya. "Synthesis of deuterium-labelled coenzyme Q10". . p. 831 - 839. Retrieved 2007/10/03.