ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Base Information

Chemical Name:ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate
CAS No.:395685-81-1
Molecular Formula:C₂₁H₂₆ClN₃O₆
Molecular Weight:451.907
Hs Code.:

Synonyms:ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Suppliers and Price of ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

There total 3 articles about ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 395685-78-6
1-benzyloxy-2-chloro-5-chloromethyl-4-methyl-1H-imidazole

: 395685-81-1
ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

1-benzyloxy-2-chloro-5-chloromethyl-4-methyl-1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 40h; Further stages.;
DOI:10.1021/jm010303j

Reference yield:

: 100-39-0
benzyl bromide

: 395685-81-1
ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.03 h / -78 °C

1.2: tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.1: 1.96 g / NaBH₄ / methanol / 3 h / 0 °C

3.1: SOCl₂ / toluene / 1 h / 0 °C

4.1: NaH / dimethylformamide / 2 h / 20 °C

4.2: 222 mg / dimethylformamide / 40 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium hydride; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010303j

Reference yield:

: 395685-72-0
3-benzyloxy-2-chloro-5-methyl-3H-imidazole-4-carbaldehyde

: 395685-81-1
ethyl 2-acetamido-3-(1-benzyloxy-2-chloro-4-methyl-5-imidazolyl)-2-ethoxycarbonylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.96 g / NaBH₄ / methanol / 3 h / 0 °C

2.1: SOCl₂ / toluene / 1 h / 0 °C

3.1: NaH / dimethylformamide / 2 h / 20 °C

3.2: 222 mg / dimethylformamide / 40 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010303j