(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

Base Information

Chemical Name:(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid
CAS No.:436100-74-2
Molecular Formula:C₂₆H₂₇N₃O₉S
Molecular Weight:557.581
Hs Code.:

Synonyms:(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

There total 1 articles about (3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-chloro-1-[(2S)-tetrahydro-2-furanyl]ethanone

: C₂₀H₁₉N₃O₇S

: 436100-74-2
(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

Guidance literature:: In dichloromethane; N,N-dimethyl acetamide; at 20 ℃;

Reference yield: 56.7%

: 436100-74-2
(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

: 655233-39-9
(6R,7R)-4-nitrobenzyl 7-amino-8-oxo-3-((S)-tetrahydrofuran-2-yl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

Guidance literature:: (3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid; With α-picoline; thionyl chloride; In dichloromethane; at -20 - -15 ℃; for 1.05h;

With sodium iodide; In dichloromethane; acetonitrile; at 5 ℃;

With α-picoline; 2-methyl-propan-1-ol; phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; lithium chloride; phosphorous acid trimethyl ester; more than 3 stages;

Reference yield:

: 436100-74-2
(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

: (3R,4R)-(4-nitrophenyl)methyl ester α-iodo-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

: (3R,4R)-(4-nitrophenyl)methyl ester α-iodo-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

Guidance literature:: (3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid; With α-picoline; thionyl chloride; In dichloromethane; at -20 - -15 ℃; for 1.05h;

With sodium iodide; In dichloromethane; acetonitrile; at 5 ℃;