(4-nitrophenyl)methyl (6R,7R)-7-amino-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride

Base Information

Chemical Name:(4-nitrophenyl)methyl (6R,7R)-7-amino-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride
CAS No.:655233-39-9
Molecular Formula:C₁₈H₁₉N₃O₆S*ClH
Molecular Weight:441.892
Hs Code.:
Mol file:655233-39-9.mol

Synonyms:

Suppliers and Price of (4-nitrophenyl)methyl (6R,7R)-7-amino-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 9 raw suppliers

Chemical Property of (4-nitrophenyl)methyl (6R,7R)-7-amino-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:441.0761342
Heavy Atom Count:29
Complexity:700

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(OC1)C2=C(N3C(C(C3=O)N)SC2)C(=O)OCC4=CC=C(C=C4)[N+](=O)[O-].Cl
Isomeric SMILES:C1C[C@H](OC1)C2=C(N3[C@@H]([C@@H](C3=O)N)SC2)C(=O)OCC4=CC=C(C=C4)[N+](=O)[O-].Cl

Technology Process of (4-nitrophenyl)methyl (6R,7R)-7-amino-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride

There total 2 articles about (4-nitrophenyl)methyl (6R,7R)-7-amino-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

: C₂₆H₂₅N₃O₇S

: 655233-39-9
(6R,7R)-4-nitrobenzyl 7-amino-8-oxo-3-((S)-tetrahydrofuran-2-yl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

Guidance literature:: With α-picoline; phosphorus pentachloride; In 2-methyl-propan-1-ol; at -55 - 20 ℃;
DOI:10.1021/op700091d

Reference yield: 56.7%

: 436100-74-2
(3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid

: 655233-39-9
(6R,7R)-4-nitrobenzyl 7-amino-8-oxo-3-((S)-tetrahydrofuran-2-yl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

Guidance literature:: (3R,4R)-(4-nitrophenyl)methyl ester α-hydroxy-2-oxo-4-[[2-oxo-2-[(1S)-(tetrahydro-2-furanyl)]ethyl]thio]-3-[(phenylacetyl)amino]-1-azetidineacetic acid; With α-picoline; thionyl chloride; In dichloromethane; at -20 - -15 ℃; for 1.05h;

With sodium iodide; In dichloromethane; acetonitrile; at 5 ℃;

With α-picoline; 2-methyl-propan-1-ol; phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; lithium chloride; phosphorous acid trimethyl ester; more than 3 stages;