1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
• CAS No.: 620534-08-9
• Molecular Formula: C₁₄H₁₁F₆N₃O₃
• Molecular Weight: 383.25

Synonyms:1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Chemical Property of 1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

There total 2 articles about 1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(azidomethyl)-3,5-bis(trifluoromethyl)benzene (620533-92-8) + diethyl malonate (105-53-3) → 1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (620534-08-9)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.3987/COM-05-S(T)64

Reference yield:

1-(3,5-bis-trifluoromethyl-benzyl)-5-ethoxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (823189-50-0) → 1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (620534-08-9)

Guidance literature:

With hydrogenchloride; In water;

Reference yield: 95.0%

1-(3,5-bis-trifluoromethyl-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (620534-08-9) + dimethyl sulfate (77-78-1) → 1-(3,5-bis-trifluoromethyl-benzyl)-5-methoxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (823188-35-8)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 18h;

upstream raw materials:

1-(azidomethyl)-3,5-bis(trifluoromethyl)benzene

diethyl malonate

1-(3,5-bis-trifluoromethyl-benzyl)-5-ethoxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Downstream raw materials:

1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazole-4-carbaldehyde

1-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-4-(tert-butyl-dimethyl-silanyloxy)-but-2-yn-1-one

[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-chloro-pyridin-4-yl)-isoxazol-4-yl]-methanone

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