1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine

Base Information

Chemical Name:1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine
CAS No.:568-76-3
Molecular Formula:C₁₉H₂₀N₂O₃
Molecular Weight:324.379
Hs Code.:
DSSTox Substance ID:DTXSID50972248
Nikkaji Number:J13.869J
ChEMBL ID:CHEMBL3544829
Mol file:568-76-3.mol

Synonyms:(+-)-isomer of gamma-hydroxyphenylbutazone;1,2-diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine;gamma-hydroxyphenylbutazone

Suppliers and Price of 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
gamma-Hydroxy phenylbutazone
2mg
$ 350.00

American Custom Chemicals Corporation
GAMMA-HYDROXY PHENYLBUTAZONE 95.00%
5G
$ 2656.50

American Custom Chemicals Corporation
GAMMA-HYDROXY PHENYLBUTAZONE 95.00%
100MG
$ 1871.10

American Custom Chemicals Corporation
GAMMA-HYDROXY PHENYLBUTAZONE 95.00%
10MG
$ 739.20

Total 5 raw suppliers

Chemical Property of 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine

Chemical Property:

Vapor Pressure:1.53E-09mmHg at 25°C
Boiling Point:467.5°Cat760mmHg
Flash Point:236.6°C
PSA：60.85000
Density:1.244g/cm³
LogP:2.88860
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:324.14739250
Heavy Atom Count:24
Complexity:420

Purity/Quality:

99% ^*data from raw suppliers

gamma-Hydroxy phenylbutazone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3)O
Uses Labelled γ-Hydroxy Phenylbutazone (H940070). γ-Hydroxy Phenylbutazone is a metabolite of Kebuzone (K155300). Antirheumatic.

Technology Process of 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine

There total 6 articles about 1,2-Diphenyl-3,5-dioxo-4-(3-hydroxybutyl)pyrazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853-34-9
kebuzone

: 568-76-3
hydroxyphenylbutazone

: 96740-75-9
6-methyl-2-oxo-tetrahydro-pyran-3-carboxylic acid-(N,N'-diphenyl-hydrazide)

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; Hydrogenation;
DOI:10.1002/hlca.19570400219

Reference yield:

: 7796-23-8
(3-oxybutyl)malonate ethylene ketal

: 568-76-3
hydroxyphenylbutazone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate; benzene

2: toluene-4-sulfonic acid; acetone

3: Raney nickel; aq.-ethanolic NaOH / Hydrogenation

With sodium hydroxide; sodium methylate; nickel; toluene-4-sulfonic acid; acetone; benzene;
DOI:10.1002/hlca.19570400219

Reference yield:

: 116604-64-9
4-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione

: 568-76-3
hydroxyphenylbutazone

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; acetone

2: Raney nickel; aq.-ethanolic NaOH / Hydrogenation

With sodium hydroxide; nickel; toluene-4-sulfonic acid; acetone;
DOI:10.1002/hlca.19570400219