N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Base Information

Chemical Name:N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide
CAS No.:69082-42-4
Molecular Formula:C₂₀H₂₂ClN₃O₄
Molecular Weight:403.865
Hs Code.:

Synonyms:N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

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Chemical Property of N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

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Technology Process of N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

There total 7 articles about N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 69082-40-2
N-(5-chloro-2-methoxyphenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

: 69082-42-4
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Guidance literature:: With sulfuric acid; nitric acid; In acetic acid; at 30 - 35 ℃; for 4h;
DOI:10.1021/jm00366a017

Reference yield:

: 95-03-4
5-chloro-2-methoxyaniline

: 69082-42-4
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) thionyl chloride / 1.) HMPA, 30 min, 2.) HMPA, RT, overnight

2: dimethylformamide / 4 h / 110 °C

3: H₂ / PtO₂ / ethanol / 6 h / 12928.7 Torr / Ambient temperature

4: 78 percent / HNO₃, H₂SO₄ / acetic acid / 4 h / 30 - 35 °C

With thionyl chloride; sulfuric acid; hydrogen; nitric acid; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00366a017

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 69082-42-4
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) thionyl chloride / 1.) HMPA, 30 min, 2.) HMPA, RT, overnight

2: dimethylformamide / 4 h / 110 °C

3: H₂ / PtO₂ / ethanol / 6 h / 12928.7 Torr / Ambient temperature

4: 78 percent / HNO₃, H₂SO₄ / acetic acid / 4 h / 30 - 35 °C

With thionyl chloride; sulfuric acid; hydrogen; nitric acid; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00366a017