N-(4-amino-5-chloro-2-methoxyphenyl)-1-benzylpiperidine-4-carboxamide dihydrochloride

Base Information

Chemical Name:N-(4-amino-5-chloro-2-methoxyphenyl)-1-benzylpiperidine-4-carboxamide dihydrochloride
CAS No.:69082-47-9
Molecular Formula:C₂₀H₂₄ClN₃O₂
Molecular Weight:373.882
Hs Code.:

Synonyms:N-(4-amino-5-chloro-2-methoxyphenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

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Chemical Property of N-(4-amino-5-chloro-2-methoxyphenyl)-1-benzylpiperidine-4-carboxamide dihydrochloride

Chemical Property:

Vapor Pressure:2.09E-09mmHg at 25°C

Purity/Quality:

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Technology Process of N-(4-amino-5-chloro-2-methoxyphenyl)-1-benzylpiperidine-4-carboxamide dihydrochloride

There total 8 articles about N-(4-amino-5-chloro-2-methoxyphenyl)-1-benzylpiperidine-4-carboxamide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 69082-42-4
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

: 69082-47-9
N-(4-amino-5-chloro-2-methoxyphenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In acetic acid; Ambient temperature;
DOI:10.1021/jm00366a017

Reference yield:

: 95-03-4
5-chloro-2-methoxyaniline

: 69082-47-9
N-(4-amino-5-chloro-2-methoxyphenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) thionyl chloride / 1.) HMPA, 30 min, 2.) HMPA, RT, overnight

2: dimethylformamide / 4 h / 110 °C

3: H₂ / PtO₂ / ethanol / 6 h / 12928.7 Torr / Ambient temperature

4: 78 percent / HNO₃, H₂SO₄ / acetic acid / 4 h / 30 - 35 °C

5: 63 percent / SnCl₂, conc. HCl / acetic acid / Ambient temperature

With hydrogenchloride; thionyl chloride; sulfuric acid; hydrogen; nitric acid; tin(ll) chloride; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00366a017

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 69082-47-9
N-(4-amino-5-chloro-2-methoxyphenyl)-1-(phenylmethyl)-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) thionyl chloride / 1.) HMPA, 30 min, 2.) HMPA, RT, overnight

2: dimethylformamide / 4 h / 110 °C

3: H₂ / PtO₂ / ethanol / 6 h / 12928.7 Torr / Ambient temperature

4: 78 percent / HNO₃, H₂SO₄ / acetic acid / 4 h / 30 - 35 °C

5: 63 percent / SnCl₂, conc. HCl / acetic acid / Ambient temperature

With hydrogenchloride; thionyl chloride; sulfuric acid; hydrogen; nitric acid; tin(ll) chloride; platinum(IV) oxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00366a017