methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate

Base Information

Chemical Name:methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate
CAS No.:1395990-04-1
Molecular Formula:C₁₈H₁₈F₃NO₄
Molecular Weight:369.34
Hs Code.:

Synonyms:methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate

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Technology Process of methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate

There total 2 articles about methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1395989-97-5
methyl 6-[2,6-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-5-fluoropyridine-2-carboxylate

: 74-88-4
methyl iodide

: 1395990-04-1
methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 1395989-83-9
methyl 6-(2,6-difluoro-4-(2-methyl-2-((triethylsilyl)oxy)propoxy)phenyl)-5-fluoropicolinate

: 1395990-04-1
methyl 6-(2,6-difluoro-4-(2-methoxy-2-methylpropoxy)phenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran; methanol / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydrogenchloride; water; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;