Technology Process of N-(benzofuran-2-yl)-N-methylbenzamide
There total 6 articles about N-(benzofuran-2-yl)-N-methylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(benzofuran-2-yl)benzamide;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.25h;
Inert atmosphere;
methyl iodide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo102265b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium thiosulfate / ethyl acetate / 1 h / 0 °C / Inert atmosphere
2.1: palladium diacetate; cesium fluoride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,1-dimethoxyethane; water / 10 h / Inert atmosphere; Reflux
3.1: dmap; sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere
3.2: 16 h / Inert atmosphere; Reflux
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
With
dmap; palladium diacetate; sodium hydride; sodium thiosulfate; cesium fluoride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,1-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
2.1: Suzuki-Miyaura reaction;
DOI:10.1021/jo102265b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / 1,4-dioxane; water / 1 h / 101 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; cesium fluoride;
In
1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;
1.1: Suzuki-Miyaura reaction;
DOI:10.1021/jo102265b
