cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

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Chemical Name:cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate
CAS No.:1192247-54-3
Molecular Formula:C₂₂H₂₆F₄N₄O₂S₂
Molecular Weight:518.6
Hs Code.:

Synonyms:cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

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Chemical Property of cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

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Technology Process of cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

There total 5 articles about cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1192247-32-7
cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

: 1192247-54-3
cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; chloroform; at 70 - 80 ℃;

Reference yield:

: 1192247-80-5
ethyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

: 1192247-54-3
cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h

1.2: pH 2 - 3

2.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

3.1: Lawessons reagent / 1,2-dimethoxyethane; chloroform / 70 - 80 °C

With Lawessons reagent; dmap; lithium hydroxide monohydrate; water; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; chloroform;

Reference yield:

: 1192247-90-7
2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid

: 1192247-54-3
cyclohexyl 2-(1-{2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethanethioyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

2: Lawessons reagent / 1,2-dimethoxyethane; chloroform / 70 - 80 °C

With Lawessons reagent; dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dimethoxyethane; dichloromethane; chloroform;