cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

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Chemical Name:cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate
CAS No.:1192247-32-7
Molecular Formula:C₂₂H₂₆F₄N₄O₃S
Molecular Weight:502.533
Hs Code.:

Synonyms:cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

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Chemical Property of cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

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Technology Process of cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

There total 4 articles about cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1192247-90-7
2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylic acid

: 108-93-0
cyclohexanol

: 1192247-32-7
cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

: 365413-31-6
ethyl 2-(1-(tert-butoxy carbonyl )piperidin-4-yl)thiazole-4-carboxylate

: 1192247-32-7
cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / diethyl ether / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

2.2: 24 h / 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h

3.2: pH 2 - 3

4.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

With hydrogenchloride; dmap; oxalyl dichloride; lithium hydroxide monohydrate; water; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 922516-41-4
2-piperidin-4-yl-thiazole-4-carboxylic acid ethyl ester hydrochloride

: 1192247-32-7
cyclohexyl 2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

1.2: 24 h / 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h

2.2: pH 2 - 3

3.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

With dmap; oxalyl dichloride; lithium hydroxide monohydrate; water; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;