N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester

Base Information

• Chemical Name: N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester
• CAS No.: 1061261-89-9
• Molecular Formula: C₂₃H₃₅N₃O₆S
• Molecular Weight: 481.613

Synonyms:N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester

Chemical Property of N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester

There total 4 articles about N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyloxycarbonyl isothiocyanate (63220-36-0) + tert-butyl (2S)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate (53054-03-8) → Nω-benzyloxycarbonyl-Nα-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester (1061261-89-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1039/c0ob01117g

Reference yield: 93.0%

Nα-tert-butyloxycarbonyl-L-ornithine tert-butyl ester hydrochloride + benzyloxycarbonyl isothiocyanate (63220-36-0) → Nω-benzyloxycarbonyl-Nα-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester (1061261-89-9)

Guidance literature:

N^α-tert-butyloxycarbonyl-L-ornithine tert-butyl ester hydrochloride; With ammonia; In dichloromethane;

benzyloxycarbonyl isothiocyanate; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1055/s-2008-1067165

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → Nω-benzyloxycarbonyl-Nα-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester (1061261-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dibenzo-18-crown-6 / tetrachloroethene / 85 °C

2: CH₂Cl₂

With dibenzo-18-crown-6; In 1,1,2,2-tetrachloroethylene; dichloromethane;

DOI:10.1021/ol061454p

upstream raw materials:

benzyloxycarbonyl isothiocyanate

N_α-(1,1-dimethylethoxycarbonyl)-N_δ-(phenylmethoxycarbonyl)-L-ornithine 1,1-dimethylethyl ester

benzyl chloroformate

tert-butyl (2S)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate

Downstream raw materials:

C₂₈H₄₄N₄O₈

N^δ-{[(N-benzyloxycarbonylamino)morpholin-4-yl]methylidene}-N^α-tert-butyloxycarbonyl-L-ornithine tert-butyl ester

N^δ-{[(N-benzyloxycarbonylamino)-2,5-dihydro-1H-pyrrol-1-yl]methylidene}-N^α-tert-butyloxycarbonyl-L-ornithine tert-butyl ester

N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-N-^ω'-(2,2,2-trifluoroethyl)-L-arginine tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1061261-89-9 N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send