O-benzyl carbonisothiocyanatidate

Base Information

• Chemical Name: O-benzyl carbonisothiocyanatidate
• CAS No.: 63220-36-0
• Molecular Formula: C₉H₇NO₂S
• Molecular Weight: 193.226
• Mol file: 63220-36-0.mol

Synonyms:benzyloxycarbonyl isothiocyanate

Chemical Property of O-benzyl carbonisothiocyanatidate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Benzyl(Isothiocyanato)formate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Benzyl (Isothiocyanato)formate is an intermediate used in the synthesis of Arginino-succinic Acid Disodium Salt (A769200), which is used in the characterization of δ-crystallin in avian species.

Technology Process of O-benzyl carbonisothiocyanatidate

There total 4 articles about O-benzyl carbonisothiocyanatidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

potassium thioacyanate (333-20-0) + benzyl chloroformate (501-53-1,94274-21-2) → benzyloxycarbonyl isothiocyanate (63220-36-0)

Guidance literature:

In toluene; acetonitrile; for 48h;

DOI:10.1021/jo991458q

Reference yield:

sodium thiocyanide (540-72-7) + benzyl chloroformate (501-53-1,94274-21-2) → benzyloxycarbonyl isothiocyanate (63220-36-0)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 65 ℃; for 1h;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 1,2-diamino-benzene (95-54-5) → benzyloxycarbonyl isothiocyanate (63220-36-0)

Guidance literature:

In acetone;

upstream raw materials:

potassium thioacyanate

benzyl chloroformate

1,2-diamino-benzene

sodium thiocyanide

Downstream raw materials:

C₂₈H₄₄N₄O₈

C₂₈H₄₂F₂N₄O₈

N-benzyl-N'-benzyloxycarbonyl thiourea

N^ω-benzyloxycarbonyl-N^α-tert-butyloxycarbonyl-L-thiocitrulline tert-butyl ester

Refernces

• 1、 -. "Synthetic method of 1,3,4-thiadiazole derivative". Paragraph 0038; 0040. . Retrieved 2018/12/05.
• 2、 Kahved?i?, Amila,Nathwani, Seema-Maria,Zisterer, Daniela M.,Rozas, Isabel. "Aromatic Bis-N -hydroxyguanidinium Derivatives: Synthesis, Biophysical, and Biochemical Evaluations". supporting information. p. 451 - 459. Retrieved 2013/04/23.