4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

Base Information

Chemical Name:4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid
CAS No.:1273312-62-1
Molecular Formula:C₁₉H₁₂ClF₂NO₄S
Molecular Weight:423.824
Hs Code.:

Synonyms:4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

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Chemical Property of 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

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Technology Process of 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

There total 6 articles about 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1273312-70-1
methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

: 1273312-62-1
4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 60 ℃; for 2h;

Reference yield:

: 1273312-17-6
Methyl 2-(2,3-difluoro-4-methylphenyl)-4-oxotetrahydrothiophene-3-carboxylate

: 1273312-62-1
4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride / acetonitrile; methanol / 2.5 h / 80 °C

2: phosphorus trichloride / chlorobenzene / 1.5 h / 20 - 130 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere

4: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 60 °C

With hydroxylamine hydrochloride; boron tribromide; lithium hydroxide; phosphorus trichloride; In tetrahydrofuran; methanol; dichloromethane; water; chlorobenzene; acetonitrile;

Reference yield:

: 1273312-19-8
methyl 4-amino-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

: 1273312-62-1
4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus trichloride / chlorobenzene / 1.5 h / 20 - 130 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere

3: lithium hydroxide / water; tetrahydrofuran; methanol / 2 h / 60 °C

With boron tribromide; lithium hydroxide; phosphorus trichloride; In tetrahydrofuran; methanol; dichloromethane; water; chlorobenzene;